Expression and cellular localization of fibrillin-1 in normal and pathological human liver

L Dubuisson, S Lepreux, P Bioulac-Sage… - Journal of …, 2001 - Elsevier
Background: The expression and the distribution of fibrillin-1 and elastin were studied in
normal and pathological human liver samples. Methods: As controls, histologically
normal/subnormal liver samples (n= 24) were used. Pathological samples corresponded to
seven cirrhosis and eight hepatocellular carcinomas (HCC) developed on cirrhotic (four) or
non-cirrhotic (four) liver. Results: In normal liver, fibrillin-1 and elastin co-localized in vessel
walls and portal tract connective tissue. Fibrillin-1 alone was detected along sinusoids and …