Monitoring of serum markers for fibrosis during CCl4-induced liver damage: Effects of anti-fibrotic agents
Z Jiang, D You, X Chen, J Wu - Journal of Hepatology, 1992 - Elsevier
Liver fibrosis was induced in rats by repeated peritoneal injections of carbon tetrachloride
(CCl 4) over a period of 2–11 weeks. Serum procollagen III peptide (SPIIINP), prolidase (SP)
and alanine aminotransferase (SALT) levels were monitored during the period of induction.
The extent of fibrosis was semi-quantitatively estimated after collagen staining, and the anti-
fibrotic effects of 16, 16-dimethyl prostaglandin E 2 (DMPGE 2), colchicine, and zinc
sulphate were studied. SPIIINP and SP were increased the first 2 weeks after CCl 4 …
(CCl 4) over a period of 2–11 weeks. Serum procollagen III peptide (SPIIINP), prolidase (SP)
and alanine aminotransferase (SALT) levels were monitored during the period of induction.
The extent of fibrosis was semi-quantitatively estimated after collagen staining, and the anti-
fibrotic effects of 16, 16-dimethyl prostaglandin E 2 (DMPGE 2), colchicine, and zinc
sulphate were studied. SPIIINP and SP were increased the first 2 weeks after CCl 4 …
