Human neurodegenerative disease modeling using Drosophila
NM Bonini, ME Fortini - Annual review of neuroscience, 2003 - annualreviews.org
NM Bonini, ME Fortini
Annual review of neuroscience, 2003•annualreviews.org▪ Abstract A number of approaches have been taken to recreate and to study the role of
genes associated with human neurodegenerative diseases in the model organism
Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease,
Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as
an important model system in which to study the fundamental pathways influenced by these
genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.
genes associated with human neurodegenerative diseases in the model organism
Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease,
Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as
an important model system in which to study the fundamental pathways influenced by these
genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.
▪ Abstract
A number of approaches have been taken to recreate and to study the role of genes associated with human neurodegenerative diseases in the model organism Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease, Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as an important model system in which to study the fundamental pathways influenced by these genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.
Annual Reviews