The C terminus of CFTR contains a PDZ interacting domain that is required for the polarized
expression of cystic fibrosis transmembrane conductance regulator (CFTR) in the apical
plasma membrane of polarized epithelial cells. To elucidate the mechanism whereby the
PDZ interacting domain mediates the polarized expression of CFTR, Madin-Darby canine
kidney cells were stably transfected with wild type (wt-CFTR) or C-terminally truncated
human CFTR (CFTR-ΔTRL). We tested the hypothesis that the PDZ interacting domain …