Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor
AY Khakoo, CM Kassiotis, N Tannir… - … Journal of the …, 2008 - Wiley Online Library
AY Khakoo, CM Kassiotis, N Tannir, JC Plana, M Halushka, C Bickford, J Trent 2nd…
Cancer: Interdisciplinary International Journal of the American …, 2008•Wiley Online LibraryBACKGROUND. Sunitinib malate is a novel multitargeted receptor tyrosine kinase inhibitor
with established efficacy in the treatment of metastatic renal cell carcinoma and imatinib‐
resistant gastrointestinal stromal tumor. This report describes the development of heart
failure in cancer patients who received this novel agent. METHODS. A retrospective study
was conducted at MD Anderson Cancer Center during a 1‐year period on patients who
received sunitinib and developed heart failure. RESULTS. During 2006, 6 of 224 (2.7%) …
with established efficacy in the treatment of metastatic renal cell carcinoma and imatinib‐
resistant gastrointestinal stromal tumor. This report describes the development of heart
failure in cancer patients who received this novel agent. METHODS. A retrospective study
was conducted at MD Anderson Cancer Center during a 1‐year period on patients who
received sunitinib and developed heart failure. RESULTS. During 2006, 6 of 224 (2.7%) …
BACKGROUND
Sunitinib malate is a novel multitargeted receptor tyrosine kinase inhibitor with established efficacy in the treatment of metastatic renal cell carcinoma and imatinib‐resistant gastrointestinal stromal tumor. This report describes the development of heart failure in cancer patients who received this novel agent.
METHODS
A retrospective study was conducted at M. D. Anderson Cancer Center during a 1‐year period on patients who received sunitinib and developed heart failure.
RESULTS
During 2006, 6 of 224 (2.7%) patients who received sunitinib developed heart failure (HF) that resulted in substantial morbidity and, in some cases, mortality. Symptomatic heart failure occurred soon after initiation of sunitinib (mean onset 22 days after initiation), was associated with decline in cardiac function and elevations in blood pressure, and was not completely reversible in most patients, even after termination of sunitinib therapy.
CONCLUSIONS
These observations suggested that sunitinib‐associated heart failure may represent a potentially serious toxicity and underscore the need for careful monitoring of cardiac function and aggressive control of hypertension in these patients. Studies to elucidate potential mechanisms of heart failure and left ventricular dysfunction resulting from treatment with sunitinib are necessary to develop strategies for prevention and treatment of this complication. Cancer 2008. ©2008 American Cancer Society.
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