PD-1 blockade: rescue from a near-death experience
JN Blattman, PD Greenberg - Nature immunology, 2006 - nature.com
Nature immunology, 2006•nature.com
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It is unclear whether T cell exhaustion is reversible. A recent Nature paper shows that in vivo blockade of the inhibitory molecule PD-1 can restore the function of exhausted CD8+ T cells during chronic viral infection.
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