Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium
G Serrero, OB Ioffe - Human pathology, 2003 - Elsevier
PC-cell-derived growth factor (PCDGF, progranulin) is a novel autocrine growth factor that is
overexpressed in human breast cancer cell lines. We have examined immunohistochemical
PCDGF expression in 206 paraffin-embedded human breast lesions and investigated its
association with clinicopathological variables. PCDGF staining was observed in breast
carcinoma, whereas it was almost always negative in benign breast epithelium. PCDGF
expression was more common in invasive ductal carcinoma (80% cases positive) than in …
overexpressed in human breast cancer cell lines. We have examined immunohistochemical
PCDGF expression in 206 paraffin-embedded human breast lesions and investigated its
association with clinicopathological variables. PCDGF staining was observed in breast
carcinoma, whereas it was almost always negative in benign breast epithelium. PCDGF
expression was more common in invasive ductal carcinoma (80% cases positive) than in …
