[HTML][HTML] The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component
V Shalak, M Kaminska, R Mitnacht-Kraus… - Journal of Biological …, 2001 - ASBMB
Endothelial-monocyte-activating polypeptide II (EMAPII) is an inflammatory cytokine
released under apoptotic conditions. Its proEMAPII precursor proved to be identical to the
auxiliary p43 component of the aminoacyl-tRNA synthetase complex. We show here that the
EMAPII domain of p43 is released readily from the complex after in vitro digestion with
caspase 7 and is able to induce migration of human mononuclear phagocytes. The N
terminus ofin vitro-processed EMAPII coincides exactly with that of the mature cytokine …
released under apoptotic conditions. Its proEMAPII precursor proved to be identical to the
auxiliary p43 component of the aminoacyl-tRNA synthetase complex. We show here that the
EMAPII domain of p43 is released readily from the complex after in vitro digestion with
caspase 7 and is able to induce migration of human mononuclear phagocytes. The N
terminus ofin vitro-processed EMAPII coincides exactly with that of the mature cytokine …
