Addition of varicella zoster virus–specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients …
CKK Ma, E Blyth, L Clancy, R Simms, J Burgess… - Cytotherapy, 2015 - Elsevier
Background aims Virus-specific T-cell immunotherapy is emerging as a promising
management strategy for virus infections in patients after hematopoietic stem cell transplant
(HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T
cells prophylactically after HSCT. Methods Donor-derived cytomegalovirus (CMV)-, Epstein-
Barr virus (EBV)-, adenoviral-and varicella zoster virus (VZV)-specific T cells were generated
in a single culture and administered to HSCT patients at a dose of 2× 10 7/m 2 virus-specific …
management strategy for virus infections in patients after hematopoietic stem cell transplant
(HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T
cells prophylactically after HSCT. Methods Donor-derived cytomegalovirus (CMV)-, Epstein-
Barr virus (EBV)-, adenoviral-and varicella zoster virus (VZV)-specific T cells were generated
in a single culture and administered to HSCT patients at a dose of 2× 10 7/m 2 virus-specific …