Adoptive immunotherapy with CMV-specific cytotoxic T lymphocytes for stem cell transplant patients with refractory CMV infections
L Bao, MJ Cowan, K Dunham, B Horn… - Journal of …, 2012 - journals.lww.com
Adoptive immunotherapy with cytomegalovirus (CMV)-specific cytotoxic T lymphocytes
(CTL) is an effective strategy for preventing and treating viral reactivation after allogeneic
stem cell transplantation (SCT). We have shown previously that CMV CTL can be generated
in 1 to 2 weeks by stimulating donor lymphocytes with peptide mixes derived from full-length
pp65 and IE1. We conducted a multi-institutional study of CMV-specific CTL for patients with
persistent or anti–viral-resistant CMV infections after allogeneic SCT, to determine the …
(CTL) is an effective strategy for preventing and treating viral reactivation after allogeneic
stem cell transplantation (SCT). We have shown previously that CMV CTL can be generated
in 1 to 2 weeks by stimulating donor lymphocytes with peptide mixes derived from full-length
pp65 and IE1. We conducted a multi-institutional study of CMV-specific CTL for patients with
persistent or anti–viral-resistant CMV infections after allogeneic SCT, to determine the …