[HTML][HTML] DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
ME Durkin, MR Avner, CG Huh, BZ Yuan… - FEBS letters, 2005 - Elsevier
ME Durkin, MR Avner, CG Huh, BZ Yuan, SS Thorgeirsson, NC Popescu
FEBS letters, 2005•ElsevierDLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit
cell growth and suppress tumorigenesis. We have used homologous recombination to
inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were
phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days
post coitum. Histological analysis revealed that DLC-1−/− embryos had defects in the neural
tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos …
cell growth and suppress tumorigenesis. We have used homologous recombination to
inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were
phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days
post coitum. Histological analysis revealed that DLC-1−/− embryos had defects in the neural
tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos …
DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1−/− embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions.
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