Effects of hyperoxia and mild therapeutic hypothermia during resuscitation from porcine hemorrhagic shock
E Knöller, T Stenzel, F Broeskamp… - Critical Care …, 2016 - journals.lww.com
Objective: Hemorrhagic shock–induced tissue hypoxia induces hyperinflammation,
ultimately causing multiple organ failure. Hyperoxia and hypothermia can attenuate tissue
hypoxia due to increased oxygen supply and decreased demand, respectively. Therefore,
we tested the hypothesis whether mild therapeutic hypothermia and hyperoxia would
attenuate postshock hyperinflammation and thereby organ dysfunction. Design: Prospective,
controlled, randomized study. Setting: University animal research laboratory. Subjects: Thirty …
ultimately causing multiple organ failure. Hyperoxia and hypothermia can attenuate tissue
hypoxia due to increased oxygen supply and decreased demand, respectively. Therefore,
we tested the hypothesis whether mild therapeutic hypothermia and hyperoxia would
attenuate postshock hyperinflammation and thereby organ dysfunction. Design: Prospective,
controlled, randomized study. Setting: University animal research laboratory. Subjects: Thirty …