Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency
MK Georgieff, SA Berry, JD Wobken, EA Leibold - Placenta, 1999 - Elsevier
Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies
that are complicated by low fetal iron stores, suggesting regulation of placental iron transport
by fetoplacental iron status. In cell culture, iron homeostasis is regulated by coordinate
stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory
proteins (IRP-1 and-2) which bind to iron-responsive elements (IREs) on the respective
mRNAs. Concentrations of IRP-1, IRP-2 and TfR mRNA were measured in 10 placentae …
that are complicated by low fetal iron stores, suggesting regulation of placental iron transport
by fetoplacental iron status. In cell culture, iron homeostasis is regulated by coordinate
stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory
proteins (IRP-1 and-2) which bind to iron-responsive elements (IREs) on the respective
mRNAs. Concentrations of IRP-1, IRP-2 and TfR mRNA were measured in 10 placentae …
