Novel role for apolipoprotein E in the central nervous system: modulation of sulfatide content
It has long been postulated that apolipoprotein E (apoE) may play a role in lipid metabolism
in the brain. However, direct evidence that apoE plays such a role is lacking. We
investigated whether apoE isoforms influence lipid content in the brain. We compared the
brains of wild-type mice to apoE knockout (−/−) and human apoE3 and apoE4 transgenic
mice and compared cerebrospinal fluid (CSF) of humans with different apoE isoforms. We
found that there was no effect of apoE on the content of multiple phospholipids …
in the brain. However, direct evidence that apoE plays such a role is lacking. We
investigated whether apoE isoforms influence lipid content in the brain. We compared the
brains of wild-type mice to apoE knockout (−/−) and human apoE3 and apoE4 transgenic
mice and compared cerebrospinal fluid (CSF) of humans with different apoE isoforms. We
found that there was no effect of apoE on the content of multiple phospholipids …
