L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial
SP Schulman, LC Becker, DA Kass, HC Champion… - Jama, 2006 - jamanetwork.com
ContextThe amino acid L-arginine is a substrate for nitric oxide synthase and is increasingly
used as a health supplement. Prior studies suggest that L-arginine has the potential to
reduce vascular stiffness. ObjectiveTo determine whether the addition of L-arginine to
standard postinfarction therapy reduces vascular stiffness and improves ejection fraction
over 6-month follow-up in patients following acute ST-segment elevation myocardial
infarction. Design and SettingSingle-center, randomized, double-blind, placebo-controlled …
used as a health supplement. Prior studies suggest that L-arginine has the potential to
reduce vascular stiffness. ObjectiveTo determine whether the addition of L-arginine to
standard postinfarction therapy reduces vascular stiffness and improves ejection fraction
over 6-month follow-up in patients following acute ST-segment elevation myocardial
infarction. Design and SettingSingle-center, randomized, double-blind, placebo-controlled …
