The human mannose receptor expressed on macrophages and hepatic endothelial cells
scavenges released lysosomal enzymes, glycopeptide fragments of collagen, and
pathogenic microorganisms and thus reduces damage following tissue injury. The receptor
binds mannose, fucose, or N-acetylglucosamine (GlcNAc) residues on these targets. C-type
carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca 2+-
dependent interaction with sugars. To investigate the details of CRD4 binding, glycan array …