[HTML][HTML] Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling
The clock protein BMAL1 (brain and muscle Arnt-like protein 1) participates in circadian
regulation of lipid metabolism, but its contribution to insulin AKT-regulated hepatic lipid
synthesis is unclear. Here we used both Bmal1−/− and acute liver-specific Bmal1-depleted
mice to study the role of BMAL1 in refeeding-induced de novo lipogenesis in the liver. Both
global deficiency and acute hepatic depletion of Bmal1 reduced lipogenic gene expression
in the liver upon refeeding. Conversely, Bmal1 overexpression in mouse liver by adenovirus …
regulation of lipid metabolism, but its contribution to insulin AKT-regulated hepatic lipid
synthesis is unclear. Here we used both Bmal1−/− and acute liver-specific Bmal1-depleted
mice to study the role of BMAL1 in refeeding-induced de novo lipogenesis in the liver. Both
global deficiency and acute hepatic depletion of Bmal1 reduced lipogenic gene expression
in the liver upon refeeding. Conversely, Bmal1 overexpression in mouse liver by adenovirus …
