G protein βγ subunits: central mediators of G protein-coupled receptor signaling
AV Smrcka - Cellular and molecular life sciences, 2008 - Springer
Cellular and molecular life sciences, 2008•Springer
G protein βγ subunits are central participants in G protein-coupled receptor signaling
pathways. They interact with receptors, G protein α subunits and downstream targets to
coordinate multiple, different GPCR functions. Much is known about the biology of Gβγ
subunits but mysteries remain. Here, we will review what is known about general aspects of
structure and function of Gβγ as well as discuss emerging mechanisms for regulation of Gβγ
signaling. Recent data suggest that Gβγ is a potential therapeutic drug target. Thus, a …
pathways. They interact with receptors, G protein α subunits and downstream targets to
coordinate multiple, different GPCR functions. Much is known about the biology of Gβγ
subunits but mysteries remain. Here, we will review what is known about general aspects of
structure and function of Gβγ as well as discuss emerging mechanisms for regulation of Gβγ
signaling. Recent data suggest that Gβγ is a potential therapeutic drug target. Thus, a …
Abstract
G protein βγ subunits are central participants in G protein-coupled receptor signaling pathways. They interact with receptors, G protein α subunits and downstream targets to coordinate multiple, different GPCR functions. Much is known about the biology of Gβγ subunits but mysteries remain. Here, we will review what is known about general aspects of structure and function of Gβγ as well as discuss emerging mechanisms for regulation of Gβγ signaling. Recent data suggest that Gβγ is a potential therapeutic drug target. Thus, a thorough understanding of the molecular and physiological functions of Gβγ has significant implications.
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