Throughout the past five decades, tremendous advancements have been made in our
understanding of G protein signaling and presynaptic inhibition, many of which were
published in the Journal of Biological Chemistry under the tenure of Herb Tabor as Editor-in-
Chief. Here, we identify these critical advances, including the formulation of the ternary
complex model of G protein–coupled receptor signaling and the discovery of Gβγ as a
critical signaling component of the heterotrimeric G protein, along with the nature of …