[HTML][HTML] Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
A Koul, L Vranckx, N Dendouga, W Balemans… - Journal of Biological …, 2008 - ASBMB
An estimated one-third of the world population is latently infected with Mycobacterium
tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-
tuberculosis drugs, such as isoniazid. We recently identified diarylquinoline R207910 (also
called TMC207) as an inhibitor of ATP synthase with a remarkable activity against
replicating mycobacteria. In the present study, we show that R207910 kills dormant bacilli as
effectively as aerobically grown bacilli with the same target specificity. Despite a …
tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-
tuberculosis drugs, such as isoniazid. We recently identified diarylquinoline R207910 (also
called TMC207) as an inhibitor of ATP synthase with a remarkable activity against
replicating mycobacteria. In the present study, we show that R207910 kills dormant bacilli as
effectively as aerobically grown bacilli with the same target specificity. Despite a …
