Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium
M Semmler-Behnke, S Takenaka… - Environmental …, 2007 - ehp.niehs.nih.gov
Background There is ongoing discussion that inhaled nanoparticles (NPs,< 100 nm) may
translocate from epithelial deposition sites of the lungs to systemic circulation. Objectives
and Methods We studied the disappearance of NPs from the epithelium by sequential lung
retention and clearance and bronchoalveolar lavage (BAL) measurements in healthy adult
Wistar Kyoto (WKY) rats at various times over 6 months after administration of a single 60-to
100-min intratracheal inhalation of iridium-192 (192Ir)–radiolabeled NPs. A complete 192Ir …
translocate from epithelial deposition sites of the lungs to systemic circulation. Objectives
and Methods We studied the disappearance of NPs from the epithelium by sequential lung
retention and clearance and bronchoalveolar lavage (BAL) measurements in healthy adult
Wistar Kyoto (WKY) rats at various times over 6 months after administration of a single 60-to
100-min intratracheal inhalation of iridium-192 (192Ir)–radiolabeled NPs. A complete 192Ir …