[HTML][HTML] Subcellular localization of the autoimmune regulator protein: characterization of nuclear targeting and transcriptional activation domain
J Pitkänen, P Vähämurto, K Krohn… - Journal of Biological …, 2001 - ASBMB
The autoimmune regulator (AIRE) gene, defective in the hereditary autoimmune disease
APECED, encodes a transcriptional regulator protein. AIRE is expressed in the medullary
epithelial cells and monocyte-dendritic cells of the thymus with lower expression in the
spleen, fetal liver, and lymph nodes. At the cellular level, AIRE is located in microtubular
structures of the cytoskeleton and in discrete nuclear dots resembling ND10 nuclear bodies.
We studied the determinants of the targeting of AIRE into these structures. We report here …
APECED, encodes a transcriptional regulator protein. AIRE is expressed in the medullary
epithelial cells and monocyte-dendritic cells of the thymus with lower expression in the
spleen, fetal liver, and lymph nodes. At the cellular level, AIRE is located in microtubular
structures of the cytoskeleton and in discrete nuclear dots resembling ND10 nuclear bodies.
We studied the determinants of the targeting of AIRE into these structures. We report here …