[HTML][HTML] Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells
B Lagerwaard, MD van der Hoek, J Hoeks… - Mechanisms of Ageing …, 2021 - Elsevier
Protein acylation via metabolic acyl-CoA intermediates provides a link between cellular
metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine-
tuned is during myogenic differentiation. However, the roles of other protein acylations
remain unknown. Protein propionylation could be functionally relevant because propionyl-
CoA can be derived from the catabolism of amino acids and fatty acids and was shown to
decrease during muscle differentiation. We aimed to explore the potential role of protein …
metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine-
tuned is during myogenic differentiation. However, the roles of other protein acylations
remain unknown. Protein propionylation could be functionally relevant because propionyl-
CoA can be derived from the catabolism of amino acids and fatty acids and was shown to
decrease during muscle differentiation. We aimed to explore the potential role of protein …