Diet-induced obesity is associated with altered expression of sperm motility-related genes and testicular post-translational modifications in a mouse model
F Wang, H Chen, Y Chen, Y Cheng, J Li, L Zheng… - Theriogenology, 2020 - Elsevier
Obesity is a metabolic disease and its relation with male subfertility has aroused a growing
concern. However, it is unclear whether gene expression and post-translational
modifications (PTMs), two vital molecular mechanisms regulating cellular functions, are
associated with obesity-induced male reproductive dysfunction. In this study, male obesity
with compromised sperm motility was induced by a high-fat diet (HFD) using a mouse
model. The expression of motility related-genes, the level of histone modifications, and the …
concern. However, it is unclear whether gene expression and post-translational
modifications (PTMs), two vital molecular mechanisms regulating cellular functions, are
associated with obesity-induced male reproductive dysfunction. In this study, male obesity
with compromised sperm motility was induced by a high-fat diet (HFD) using a mouse
model. The expression of motility related-genes, the level of histone modifications, and the …
