[HTML][HTML] Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis
MB Mehta, SV Shewale, RN Sequeira, JS Millar… - Journal of Biological …, 2017 - ASBMB
Maintenance of whole-body glucose homeostasis is critical to glycemic function. Genetic
variants mapping to chromosome 8p23. 1 in genome-wide association studies have been
linked to glycemic traits in humans. The gene of known function closest to the mapped
region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a protein (GL)
that regulates glycogen metabolism in the liver. We therefore sought to test the hypothesis
that hepatic PPP1R3B is associated with glycemic traits. We generated mice with either liver …
variants mapping to chromosome 8p23. 1 in genome-wide association studies have been
linked to glycemic traits in humans. The gene of known function closest to the mapped
region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a protein (GL)
that regulates glycogen metabolism in the liver. We therefore sought to test the hypothesis
that hepatic PPP1R3B is associated with glycemic traits. We generated mice with either liver …