Cytosolic PEP can be disposed of by two routes. First, a portion is converted to pyruvate because of the presence of the glycolytic enzyme pyruvate kinase. This creates a complicated substrate cycle between pyruvate and PEP. Second, the remaining PEP is converted to fructose 1, 6-bisphosphate (Fru 1, 6-P2) by enzymes that are common to both gluн coneogenesis and glycolysis. Fru 1, 6-P2 is converted then to fructose 6-phosphate (Fru 6-P) by fructose-l, 6-bisphosphatase (Fru-l, 6-P2ase). Howevн er, the presence of the glycolytic enzyme 6-phosphofructo-l-kinase (6PFIK) also creates a second substrate cycle between Fru 1, 6-P2 and Fru 6-P. The fraction of Fru 6-P not recycled to Fru 1, 6-Pz is converted to glucose

6-phosphate by gIucose-6-phosphate isomerase. The final step in the pathн way is the conversion of glucose 6-phosphate to glucose by glucose-6-phosн phatase (Glu-6-Pase). However, the presence of the glycolytic enzymes