[HTML][HTML] Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice
JM Irimia, CM Meyer, CL Peper, L Zhai, CB Bock… - Journal of Biological …, 2010 - ASBMB
Conversion to glycogen is a major fate of ingested glucose in the body. A rate-limiting
enzyme in the synthesis of glycogen is glycogen synthase encoded by two genes, GYS1,
expressed in muscle and other tissues, and GYS2, primarily expressed in liver (liver
glycogen synthase). Defects in GYS2 cause the inherited monogenic disease glycogen
storage disease 0. We have generated mice with a liver-specific disruption of the Gys2 gene
(liver glycogen synthase knock-out (LGSKO) mice), using Lox-P/Cre technology. Conditional …
enzyme in the synthesis of glycogen is glycogen synthase encoded by two genes, GYS1,
expressed in muscle and other tissues, and GYS2, primarily expressed in liver (liver
glycogen synthase). Defects in GYS2 cause the inherited monogenic disease glycogen
storage disease 0. We have generated mice with a liver-specific disruption of the Gys2 gene
(liver glycogen synthase knock-out (LGSKO) mice), using Lox-P/Cre technology. Conditional …