Clinically significant signs and symptoms of hemolysis can result from the transfusion of
crossmatch incompatible blood, the development of anti–red blood cell (RBC) alloantibodies
posttransfusion, or the development of autoantibodies to RBCs (ie, autoimmune hemolytic
anemia). However, a less understood and poorly appreciated phenomenon is when an
antibody induces the loss of its target antigen without significant damage to the cells
themselves. This has been referred to as “depressed antigen,”“antigen suppression,”“ …